Synthesis of Haplomyrtin Analogs

Abstract

<p>Previous research has shown that the 1arylnaphthalene lignan lactones occur widespread in nature and have a diverse range of biological activity. A route to the synthesis of Haplomyrtin has been investigated in which 12 separate steps were employed with an overall yield of 13%. In order to improve the total synthesis route and the yield, a novel approach is being investigated. This approach uses phthalide as a starting material. As a preliminary study for the use of an appropriately substituted phthalide in the synthesis of Haplomyrtin, an investigation of the electrophilic aromatic substitution reactions of phthalide as well as the generation of several hydroxy and halo phthalide precursors has been undertaken.</p><p>This presentation occurred at the Wright State University Campus-Wide Celebration of Research, Scholarship and Creative Activities on April 16, 2010</p>