Microwave-Assisted N-Alkylations of Isatins

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Microwave-Assisted N-Alkylations of Isatins

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dc.contributor Ketcha, Daniel
dc.contributor.author Clay, Charles
dc.coverage.temporal 2010 en_US
dc.date.accessioned 2011-06-15T17:05:08Z
dc.date.available 2011-06-15T17:05:08Z
dc.date.created 2010-04
dc.date.issued 2010-04
dc.identifier.other celebration_abstract10_clay_c
dc.identifier.uri http://hdl.handle.net/2374.WSU/4707
dc.description.abstract

In light of the fact that oxindoles undergo alkylation at both the nitrogen and the C-3 position, one route to regioisomerically produced N-alkyl oxindoles involves a two step process involving N-alkylation of the corresponding isatin followed by reductive deoxygenation of the isatin. We report that isatins can be efficiently N-alkylated using a variety of bases under microwave conditions. These isatins then seve as precursors to oxindoles using Wolff-Kishner conditions.

This presentation occurred at the Wright State University Campus-Wide Celebration of Research, Scholarship and Creative Activities on April 16, 2010

dc.language.iso en_US en_US
dc.publisher Wright State University en_US
dc.relation.ispartof Celebration of Research, Scholarship, and Creative Activities en_US
dc.rights.uri http://www.wright.edu/web/copyright.html
dc.subject Clay, Charles en_US
dc.subject Ketcha, Daniel en_US
dc.subject Wright State University. College of Science and Mathematics. Department of Chemistry en_US
dc.title Microwave-Assisted N-Alkylations of Isatins en_US
dc.type Presentation en_US
dc.permissions World
dc.publisher.digital Digital Services Department, Wright State University Libraries en_US
dc.date.digitized 2010-04
dc.publisher.OLinstitution Wright State University

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