Acylation of Sydnones Using Montmorillonite K-10 Clay and a Variety of Anhudrides: Thermal vs. Microwave Irradiation

Abstract

<p>A variety of 3-phenyl-4-acylsydnones were synthesized using Montmorillonite K-10 clay as catalyst and a variety of anhydrides (Scheme 1). The efficiency of thermal heating versus microwave irradiation was explored. Thermally, the acylated sydnones were synthesized in good yields after a time period of 24 hours, for the simplest anhydrides, and up to many days for the more complicated anhydrides. With the use of microwave irradiation the rate of the reaction was significantly increased bringing reaction times down to mere hours. The scope and limitations of the process will be discussed. Scheme 1: General scheme showing acylation of 3-phenylsydnone.</p><p>This presentation occurred at the Wright State University Campus-Wide Celebration of Research, Scholarship and Creative Activities on April 16, 2010</p>