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Abstract:
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There is no drug that is successful in preventing emesis elicited by all stimuli. Commercially available anti-emetic drugs act on specific pathways and are not effective on all types of emesis. The aim of this study is to test ETI-415 for efficacy against multiple emetic stimuli using both drug-induced emesis and motion sickness. ETI-415 is a novel anti-emetic developed as a second generation drug to follow ETI-385. It has not been tested previously. Testing was done using a species of musk shrew, Suncus murinis, an animal commonly used in emetic research, with stimuli of nicotine at a dose of 10mg/kg to activate the chemical trigger zone and motion at a frequency of 1.0Hz to disturb the vestibular processing to elicit motion sickness. ETI-415 was a potent drug effective against both stimuli. Its duration of action will be determined and compared with that of the prior drug and receive further testing in a second species. |
